Activation of Cortical Type 2 Cannabinoid Receptors Ameliorates Ischemic Brain Injury, Study Suggests


Feb. 21, 2013 — A new study published in the March issue of The American Journal of Pathology suggests that cortical type 2 cannabinoid (CB2) receptors might serve as potential therapeutic targets for cerebral ischemia.

Researchers found that the cannabinoid trans-caryophyllene (TC) protected brain cells from the effects of ischemia in both in vivo and in vitro animal models. In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema. In cell cultures composed of rat cortical neurons and glia exposed to oxygen-glucose deprivation and reoxygenation (OGD/R), TC decreased neuronal injury and mitochondrial depolarization, specifically through type 2 cannabinoid receptor (CB2R) pathways.

“To our knowledge, novel data presented in this study provide evidence for the first time supporting a previously unappreciated role of cortical CB2R, especially neuronal CB2Rs, in ischemia,” says lead… more

Dealing With A Brain Tumor Diagnosis

There are many ways we deal with a brain tumor (BT) diagnosis. After moderating an on-line International discussion and support web site for over 15 years, with many thousands sharing their experience, I am still surprised at some of the choices we make.

The Epidermoid Brain Tumor Community web presence started in1997 and we had our first web pages published in 1998. The mission was to educate others diagnosed with this type tumor to not make the same mistake I did. I had rushed into surgery with out asking questions about the neurosurgeon’s experience, number of epidermoid BT surgeries performed, number of deaths or deficits caused by surgery, etc. In other words, I did not do my homework. I was in panic mode and just wanted the damn thing out of my head immediately. I was literally scared senseless.

Experience has indicated my response was not that abnormal. However, those who kept their emotions under control were the ones who made educated decisions and fared far better than those who had to have it out no matter what. The epidermoid BT is almost always a slow growing type of tumor/cyst. That gives one time to ask questions and seek more than one opinion.

There are many in our Community who are watch & wait (W&W) patients. Some I have known for 15 years that have still not opted for surgery simply because they can live with the mild deficits they have.

Remember, not all neurosurgeons are from the same mold. Some are highly skilled while others struggle to do their best. We have seen many of those that educated themselves travel to other countries or accross an entire contenant to have their surgery preformed by a specific neurosurgeon.

Brain surgery is not a walk in the park. It is full of risks even under the best of care. So, put the panic on the back burner while you determine what are your best choices.